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Friday, May 1, 2020 | History

9 edition of Drug-Nucleic Acid Interactions (Methods in Enzymology, Volume 340) (Methods in Enzymology) found in the catalog.

Drug-Nucleic Acid Interactions (Methods in Enzymology, Volume 340) (Methods in Enzymology)

  • 16 Want to read
  • 22 Currently reading

Published by Academic Press .
Written in English

    Subjects:
  • Enzymology,
  • Pharmacology,
  • Microbial Ecology,
  • Science,
  • Science/Mathematics,
  • Life Sciences - Biochemistry,
  • Life Sciences - Biology - Molecular Biology,
  • Research & Methodology,
  • Science / Biochemistry

  • Edition Notes

    ContributionsJonathan B. Chaires (Editor), Michael J. Waring (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages705
    ID Numbers
    Open LibraryOL9416581M
    ISBN 100121822419
    ISBN 109780121822415

      Visualization of drug-nucleic acid interactions at atomic resolution. II. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidiumiodocytidylyl (3'-5') guanosine. J Mol Biol. Aug 15; (3)– Kollman PA, Weiner PK, Dearing A. Studies of nucleotide conformations and by: Biosensors that employ nucleic acid interactions can be referred to as recognition process is based on the principle of complementary base pairing, adenine, thymine and cytosine, guanine in DNA. The hybridization probes can then base pair with the target sequences, generating an optical signal.


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Drug-Nucleic Acid Interactions (Methods in Enzymology, Volume 340) (Methods in Enzymology) Download PDF EPUB FB2

This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical Book Edition: 1.

A variety of novel methods for these studies have emerged in recent years, and Methods for Studying DNA/Drug Interactions highlights new and non-conventional methods for exploring nucleic acid/ligand interactions.

Designed to present drug-developing companies with a survey of possible future techniques, the book compares their drawbacks and Drug-Nucleic Acid Interactions book Author: Meni Wanunu.

Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses Claire J McGurk, Peter J McHugh, Michael J Tilby, Keith A Grimaldi, John A Hartley Pages Molecular Biology of the Cell: Problems Book; Essential Cell Biology; The Biology of Cancer; Case Studies in Cancer; Janeway's Immunobiology; The Immune System; Case Studies in Immunology; The Molecules of Life; Living in a Microbial World; Please accept our apologies for any inconvenience this may cause.

Purchase Protein-Nucleic Acids Interactions, Volume 91 - 1st Edition. Print Book & E-Book. ISBNAbout this book. The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite.

-The chapter by Pizarro and Sadler on metal ion-nucleic acid interactions in disease and medicine is complemented by a chapter by Lippert on coordinative bond formation between metal ions and nucleic acid bases. Together, these two chapters provide an overview of transition metal ion interactions with nucleic acids.

Nucleic acids play an important role in cellular processes including cell division (DNA replication) and protein synthesis (transcription and translation). These processes occur both in healthy cells, and in cancer cells, in which case they are targets for anti-cancer drugs.

Small molecules may interact with or bind with DNA. A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr).

The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab. Nucleic acid structure.

Transcription, Translation and Replication. Mutagenesis and DNA repair. The structural biology of protein - nucleic acid interactions is in some ways a mature field and in others in its infancy. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent : $ Request PDF | Drug–Nucleic Acid Interactions | The sections in this article are | Find, read and cite all the research you need on ResearchGateAuthor: William David Wilson.

Drug-Nucleic Acid Interactions book volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source.

Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

Drug-nucleic acid interactions. San Diego: Academic Press, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Jonathan B Chaires; Michael J Waring.

Nucleic Acid-Metal Ion Interactions provides a comprehensive review of the experimental studies that define our current understanding of the subject, with a particular emphasis on biophysical studies. The book is not merely a current review of the literature, however, as the authors also present original material and fresh perspectives.4/5(1).

Israel, May(Jerusalem Symposia): Medicine & Health Science Books @ Molecular Basis of Specificity in Nucleic Acid-Drug Interactions: Proceedings of the Twenty-Third Jerusalem Symposium on Quantum Chemistry and Author: A.

Pullman. Get this from a library. Drug-nucleic acid interactions. [Jonathan B Chaires; Michael J Waring;] -- This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source.

Techniques that are examined range from biophysical and chemical approaches to methods. Non-crystallographic 2-fold symmetry is utilized in this model drug-nucleic acid interaction, the intercalated ethidium molecule being oriented such that its phenyl and ethyl groups lie in the narrow groove of the miniature nucleic acid double-helix.

Base-pairs within the paired nucleotide units are related by a twist of 8 °. Drug-nucleic acid interactions. [Jonathan B Waring Michael J Chaires;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book: All Authors / Contributors: Jonathan B Waring Michael J Chaires.

Find more information about: ISBN: The problem is predicting the three-dimensional structure of a protein given only its primary sequence of amino acids. Simply measuring the size of an area is insufficient for the study of many aspects of protein and nucleic acid function such as substrate binding and catalysis, drug-nucleic acid interaction, and recognition by the immune system.

Visualization of drug-nucleic acid interactions at atomic resolution. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidiumiodouridylyl (3'-5') adenosine. J Mol Biol. Aug 15; (3)– Jain SC, Tsai CC, Sobell HM. Visualization of drug-nucleic acid interactions at atomic resolution.

by: 7. Classifications of DNA binding molecules - Drug interactions 8. Structures of quadruplex nucleic acids and their drug complexes 9. Solvent-accessible surfaces of proteins and nucleic acids Nucleic acid medicines as green novel anticancer drugs Correlation between nucleic acids and nanoparticle therapeutics for cancer treatment Protein-Nucleic Acids Interactions (ISSN Book 91) - Kindle edition by Donev, Rossen.

Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Protein-Nucleic Acids Interactions (ISSN Book.

Spectroscopic analysis of drug-nucleic acid interactions Article Literature Review (PDF Available) in CRC critical reviews in biochemistry 12(2) February with 77 Reads. Journals & Books; Register Sign in. VolumeIssue 3, 15 AugustPages Visualization of drug-nucleic acid interactions at atomic resolution: III.

Unifying structural concepts in understanding drug-DNA interactions and their broader implications in understanding protein-DNA interactions.

Nucleic acid drugs: A novel approach Article (PDF Available) in AFRICAN JOURNAL OF BIOTECHNOLOGY 3(12) December with Reads How we measure 'reads'. Drug-Nucleic Acid Interactions, Methods in Enzymology Vol ; find Sigma-Aldrich-M MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

Drug-Nucleic Acid Interactions, Volume (Methods in Enzymology) Hardcover Publisher: Academic Press Aug 9 Edition: ISBN: Description: Used - Very Good Very Good condition.

Volume Internal SKU: B02GSeller Rating: % positive. In addition, the affinity and specificity of a particular protein–nucleic acid interaction can be increased through protein oligomerization or multi-protein complex formation (e.g., GCN4, glucocorticoid receptor, transcription initiation complexes, mRNA splicing complexes, RISC, etc.).

The secondary and tertiary structure formed by nucleic. MOLECULAR-BASIS-OF-SPECIFICITY-IN-NUCLEIC-ACID-DRUG-INTERACTIONS Download Molecular-basis-of-specificity-in-nucleic-acid-drug-interactions ebook PDF or Read Online books in PDF, EPUB, and Mobi Format.

Click Download or Read Online button to MOLECULAR-BASIS-OF-SPECIFICITY-IN-NUCLEIC-ACID-DRUG-INTERACTIONS book pdf for free now. Nucleic Acid-Metal Ion Interactions by Simon Campbell,available at Book Depository with free delivery worldwide. By assuming an interaction between two transition dipoles, one corresponding to the visible band of the drug and the other associated with the u.v.

band of a DNA base, the same results as those of the extensive treatment of Philpott The solution spectroscopy of drugs and the drug-nucleic acid interactions () c be obtained, qualitatively Cited by: Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands.

This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively. Classifications of DNA binding molecules - Drug interactions 8. Structures of quadruplex nucleic acids and their drug complexes 9.

Solvent-accessible surfaces of proteins and nucleic acids Nucleic acid medicines as green novel anticancer drugs Correlation between nucleic acids and nanoparticle therapeutics for cancer treatment Price: $   The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy.

High-resolution structures of protein-DNA complexes have been studied since the mid s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite : Stephen Neidle. The deoxyribonucleic acid (DNA) is the molecule of life that controls all the chemical changes that take place in cells.

The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. Moreover, the knowledge of specific targets in rational design of chemotherapeutics is a fundamental factor, Author: Saad Hmoud Alotaibi, Awad Abdalla Momen.

The interplay of nucleic acid structural ensembles and ion interactions. The tethered duplex system has been used as a model system to study how ion interactions modulate the conformational.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy: Most human diseases like cancer are complex multifactorial diseases resulting from a combination of various genetic and. Nucleic-Acid Structures 1 Figure displays a single deoxyribonucleotide and the four different nucleic­ acid bases.

As may be evident, each mononucleotide along a nucleic-acidpol­ ymer contains a variety of sites for interactions with metal ions, from electro­ static interactions with the anionic phosphate backbone to soft nucleophilic File Size: 2MB. order tofind the optimal conformations for the interaction with the nucleic acids, the calculation of the charge distribution and the electrostatic potential; ii) The theoretical modeling of the drug - nucleic acid complexes in order to estimate the relative contributions to the interaction energy (van der Waals and electrostatic terms) andFile Size: KB.

If the temperature of a solution containing a helical nucleic acid is raised sufficiently, strand separation, or “melting,” occurs (1, 2, 3) (see Note 1) The temperature that marks the midpoint of the melting process is called the melting temperature (or T m) ().At the T m, half of the nucleic acid exists in the helical state and the other half exists in the single-stranded state and the Cited by:.

Nucleic acid drug development has requirements that are the same as any other modality and some that are unique. The usual factors are obvious: drug candidates need significant potency, stability in biological systems, favorable pharmacokinetics (PK), distribution and pharmacodynamics (PD).

If you are 65 or older, use amino acid injection with care. You could have more side effects. Use with care in children. Talk with the doctor. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using amino acid injection while you are class: Intravenous nutritional products.

Drug dna interaction 1. DNA Deoxyribonucleic acid, DNA, is a molecule of great biological significance. The total DNA content of a cell is termed the ‘Genome’. The ‘Genome’ is unique to an organism, and is the information bank governing all life processes of the organism, DNA being the form in which this information is stored.